Hepatobiliary Disease USMLE Step 1 Practice Question
A 20-year-old man presents with intermittent jaundice occurring during exam periods and after fasting for 12+ hours. Vital signs are normal (BP 118/76, HR 72, RR 16, Temp 98.6°F, SpO2 98%). Laboratory studies reveal unconjugated hyperbilirubinemia at 3.2 mg/dL with normal conjugated bilirubin, AST 28 U/L, ALT 32 U/L, alkaline phosphatase 68 U/L, and hemoglobin 14.8 g/dL. Abdominal ultrasound shows no gallstones or hepatic abnormalities. Which of the following is the most likely diagnosis?
Answer choices
- ACholedocholithiasis
- BAcute viral hepatitis
- CGilbert syndromeCorrect answer
- DDubin-Johnson syndrome
- ECrigler-Najjar syndrome type I
- FCrigler-Najjar syndrome type II
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