Hepatobiliary Disease USMLE Step 1 Practice Question
A 67-year-old man with a 40 pack-year smoking history presents with progressive painless jaundice, weight loss, and epigastric discomfort over 8 weeks. Vital signs: BP 138/82, HR 92, RR 16, Temp 37.2°C, SpO2 98%. Physical examination reveals a palpable nontender gallbladder and no abdominal pain. Recent laboratory studies show elevated conjugated bilirubin at 8.2 mg/dL and alkaline phosphatase 320 U/L. He recently experienced migratory thrombophlebitis. Which of the following is the most likely diagnosis?
Answer choices
- APancreatic adenocarcinoma of the headCorrect answer
- BAcute pancreatitis
- CCholangiocarcinoma
- DGallstone pancreatitis
- EPeptic ulcer disease
- FKlatskin tumor of the hepatic hilum
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