Hepatobiliary Disease USMLE Step 1 Practice Question
A 57-year-old woman with Hashimoto thyroiditis presents with progressive fatigue and intense generalized pruritus for 3 months. Vital signs: BP 128/82 mmHg, HR 76/min, RR 14/min, temp 37.2°C. Laboratory studies reveal alkaline phosphatase 320 U/L, positive antimitochondrial antibodies, and normal aminotransferases. Abdominal ultrasound shows no intrahepatic or extrahepatic bile duct dilation. She takes levothyroxine daily. Which diagnosis best explains these findings?
Answer choices
- AGilbert syndrome
- BPrimary sclerosing cholangitis
- CAcute viral hepatitis
- DPrimary biliary cholangitisCorrect answer
- EAutoimmune hepatitis
- FAlcoholic liver disease
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