Hepatobiliary Disease USMLE Step 1 Practice Question
A 21-year-old man presents with intermittent scleral icterus exacerbated by fasting and stress. Vital signs: BP 118/76, HR 82, RR 16, Temp 37°C, SpO2 98%. He denies abdominal pain and reports no weight loss. Physical examination reveals mild jaundice without hepatomegaly or splenomegaly. Laboratory studies show total bilirubin 3.2 mg/dL with unconjugated predominance; AST, ALT, and alkaline phosphatase are normal. Hemoglobin 14.2 g/dL. Which of the following is the most likely diagnosis?
Answer choices
- AAcute viral hepatitis
- BCholedocholithiasis
- CGilbert syndromeCorrect answer
- DDubin-Johnson syndrome
- ECrigler-Najjar syndrome type I
- FCrigler-Najjar syndrome type II
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