Hepatobiliary Disease USMLE Step 1 Practice Question
A 19-year-old college student presents with progressive tremor, mood changes, and jaundice over 3 months. Vital signs: BP 118/76, HR 88, RR 16, Temp 37°C, SpO2 98%. Slit lamp examination reveals Kayser-Fleischer rings at the corneal periphery. Laboratory studies show serum ceruloplasmin 15 mg/dL (normal 20-40), elevated transaminases, and INR 1.8. He denies prior hepatitis or alcohol use. Which of the following is the most likely diagnosis?
Answer choices
- AHemochromatosis
- BGilbert syndrome
- CPrimary biliary cholangitis
- DAlpha-1 antitrypsin deficiency
- EWilson diseaseCorrect answer
- FAutoimmune hepatitis
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