Hepatobiliary Disease USMLE Step 1 Practice Question
A 58-year-old man with chronic hepatitis B and cirrhosis presents with progressive weight loss and right upper quadrant discomfort. Vital signs show BP 128/76, HR 92, RR 16, Temp 37.2°C, SpO2 98%. Ultrasound reveals a 3.5-cm heterogeneous liver mass with arterial enhancement. Alpha-fetoprotein is elevated at 385 ng/mL. Prothrombin time is mildly prolonged. He denies fever or jaundice. Which diagnosis is most likely?
Answer choices
- ACholesterol polyp
- BCavernous hemangioma
- CHepatic adenoma
- DHepatocellular carcinomaCorrect answer
- EFocal nodular hyperplasia
- FAngiosarcoma of the liver
See the full explanation
Get the correct-answer rationale, why each distractor is wrong, the underlying mechanism, and high-yield associations — plus adaptive practice that targets your weak areas — with a free MedBoardPRO account.