Hematologic Malignancies USMLE Step 1 Practice Question
A 63-year-old woman presents with frequent headaches and burning pain with erythema of her hands and feet for 3 months. Vital signs: BP 148/92 mmHg, HR 94/min, RR 16/min, Temp 37.2°C, SpO2 98% on room air. Laboratory studies reveal platelet count 1,050,000/mm³, WBC 7,200/mm³, hemoglobin 13.2 g/dL, and JAK2 V617F mutation. Bone marrow biopsy shows megakaryocytic hyperplasia. Spleen is not enlarged on examination. Which diagnosis is most likely?
Answer choices
- AEssential thrombocythemiaCorrect answer
- BThrombotic thrombocytopenic purpura
- CImmune thrombocytopenia
- DAplastic anemia
- EHairy cell leukemia
- FChronic myeloid leukemia
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