Hematologic Malignancies USMLE Step 1 Practice Question
A 68-year-old man presents with progressive back pain and fatigue. Vital signs: BP 148/92, HR 88, RR 16, Temp 37.2°C, SpO2 98% on room air. Examination reveals vertebral tenderness; no lymphadenopathy noted. Laboratory studies show hemoglobin 9.0 g/dL, creatinine 2.1 mg/dL, calcium 11.8 mg/dL, and elevated total protein. Serum protein electrophoresis demonstrates a monoclonal spike. Which of the following is the most likely diagnosis?
Answer choices
- AMultiple myelomaCorrect answer
- BDiffuse large B cell lymphoma
- CFollicular lymphoma
- DWaldenstrom macroglobulinemia
- EChronic lymphocytic leukemia
- FHodgkin lymphoma
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