Hematologic Malignancies USMLE Step 1 Practice Question
A 58-year-old woman presents with a rapidly enlarging, painful left neck mass over one month. Vital signs: BP 128/82, HR 102, RR 18, Temp 37.8°C, SpO2 98%. She denies fever and night sweats. Excisional biopsy reveals diffuse sheets of large atypical B cells with high mitotic activity. Laboratory studies show LDH 580 U/L (elevated). CT chest demonstrates no mediastinal involvement. Which of the following best describes this neoplasm?
Answer choices
- APlasma cell neoplasm associated with lytic bone lesions
- BAggressive lymphoma that may arise de novo or from transformation of follicular lymphomaCorrect answer
- CIndolent leukemia of mature B cells with smudge cells
- DT cell neoplasm associated with mediastinal mass in adolescents
- ELeukemia characterized by dry tap bone marrow aspiration
- FFollicular lymphoma with waxing and waning course
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