Hematologic Malignancies USMLE Step 1 Practice Question
A 58-year-old man presents with a 3-month history of fatigue and recurrent infections. Vital signs show BP 128/82, HR 98, RR 18, Temp 37.2°C, SpO2 98%. Physical examination reveals splenomegaly but no lymphadenopathy. Laboratory studies demonstrate pancytopenia with hemoglobin 7.2 g/dL, WBC 2.1 K/μL, and platelets 45 K/μL. Bone marrow aspiration yields a dry tap. Which of the following is the most likely diagnosis?
Answer choices
- AChronic lymphocytic leukemia
- BAcute lymphoblastic leukemia
- CHairy cell leukemiaCorrect answer
- DMultiple myeloma
- EWaldenstrom macroglobulinemia
- FAcute myeloid leukemia
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