Hematologic Malignancies USMLE Step 1 Practice Question
A 41-year-old woman presents with progressive fatigue, spontaneous gingival bleeding, and easy bruising. Vital signs show BP 118/76, HR 102, RR 18, temperature 37.2°C, SpO2 98% on room air. Laboratory studies reveal WBC 8,200/μL with pancytopenia, platelet count 18,000/μL, fibrinogen 95 mg/dL, and elevated D-dimer. Bone marrow biopsy demonstrates abnormal promyelocytes with multiple Auer rods. Coagulation studies are abnormal; no recent anticoagulant use. Which of the following is the best targeted therapy?
Answer choices
- ATrastuzumab
- BImatinib
- CVincristine alone
- DAll trans retinoic acidCorrect answer
- ERituximab
- FCytarabine for AML-M2 with t(8;21)
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