Hematologic Malignancies USMLE Step 1 Practice Question
A 6-year-old boy presents with three weeks of progressive fatigue, fever, and bilateral leg pain. Vital signs: temperature 38.5°C, heart rate 118/min, blood pressure 95/60 mmHg, respiratory rate 22/min. Examination reveals pallor, petechiae, and generalized lymphadenopathy. Laboratory studies show hemoglobin 7.2 g/dL, platelets 35,000/μL, and WBC 52,000/μL with 85% lymphoblasts that are TdT positive. No hepatosplenomegaly is noted. Which of the following is the most likely diagnosis?
Answer choices
- AAcute myeloid leukemia
- BChronic lymphocytic leukemia
- CAcute lymphoblastic leukemiaCorrect answer
- DHodgkin lymphoma
- EHairy cell leukemia
- FInfectious mononucleosis with atypical lymphocytosis
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