Hematologic Malignancies USMLE Step 1 Practice Question
A 69-year-old man presents with progressive weight loss and painless diffuse lymphadenopathy. Vital signs show BP 138/82, HR 92, RR 18, temperature 37.2°C, SpO2 98%. Laboratory studies reveal hemoglobin 9.2 g/dL and elevated LDH at 520 U/L. Colonoscopy performed for anemia demonstrates numerous lymphomatous polyps throughout the colon. Lymph node biopsy reveals monoclonal B-cell population expressing CD5 and cyclin D1 but lacking CD23. No hepatosplenomegaly is noted on examination. Which diagnosis is most likely?
Answer choices
- ADiffuse large B-cell lymphoma
- BMantle cell lymphomaCorrect answer
- CHodgkin lymphoma
- DChronic lymphocytic leukemia
- EFollicular lymphoma
- FBurkitt lymphoma
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