Hematologic Malignancies USMLE Step 1 Practice Question
A 63-year-old woman presents with 3 months of painless generalized lymphadenopathy, fatigue, and night sweats. Vital signs: BP 128/82, HR 92, RR 18, Temp 37.2°C, SpO2 98%. CBC shows hemoglobin 10.2 g/dL with normal white blood cell count. Excisional lymph node biopsy demonstrates closely packed neoplastic follicles composed of centrocytes and centroblasts without diffuse large cell transformation. Which genetic abnormality is most likely present?
Answer choices
- At(14;18) with BCL2 overexpressionCorrect answer
- Bt(8;14) with c-MYC activation
- Ct(15;17) with PML-RARA fusion
- DJAK2 mutation
- Et(11;14) with cyclin D1 activation
- Ft(2;5) with ALK-NPM1 fusion
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