Hematologic Malignancies USMLE Step 1 Practice Question

A 9-year-old boy from equatorial Africa presents with a rapidly enlarging jaw mass and fever. Vital signs show temperature 38.5°C, HR 110/min, BP 105/68 mmHg, RR 22/min, SpO2 98% on room air. CBC reveals WBC 18,000/μL with 85% blasts. Jaw biopsy demonstrates sheets of medium-sized lymphoid cells with numerous tangible body macrophages creating a starry-sky appearance. He denies abdominal pain. Which genetic abnormality is most likely present?