Hematologic Malignancies USMLE Step 1 Practice Question
A 68-year-old woman presents with progressive fatigue. Vital signs show BP 128/82, HR 88, RR 16, temperature 37.2°C, SpO2 98% on room air. Laboratory studies reveal hemoglobin 13.2 g/dL, serum calcium 8.9 mg/dL, and creatinine 0.9 mg/dL. Serum protein electrophoresis demonstrates a small monoclonal spike. Bone marrow biopsy shows 6% monoclonal plasma cells. Skeletal survey reveals no lytic lesions. Which diagnosis best fits this clinical presentation?
Answer choices
- AWaldenstrom macroglobulinemia
- BSmoldering acute leukemia
- CPrimary amyloidosis due to plasma cell destruction
- DMultiple myeloma
- EMonoclonal gammopathy of undetermined significanceCorrect answer
- FLight chain disease
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