Hematologic Malignancies USMLE Step 1 Practice Question
A 66-year-old man presents with persistent lower back pain and fatigue for three weeks. Vital signs: BP 138/82, HR 92, RR 16, Temp 37.2°C, SpO2 98%. Laboratory studies reveal normocytic anemia (Hgb 9.2 g/dL), creatinine 2.1 mg/dL, calcium 11.6 mg/dL, and serum protein electrophoresis showing an M-spike. Urinalysis demonstrates Bence Jones proteins. No lymphadenopathy on examination. Which diagnosis best explains these findings?
Answer choices
- AChronic lymphocytic leukemia
- BWaldenstrom macroglobulinemia
- CMultiple myelomaCorrect answer
- DMonoclonal gammopathy of undetermined significance
- EAplastic anemia
- FLight chain disease with secondary amyloidosis
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