Hematologic Malignancies USMLE Step 1 Practice Question
A 58-year-old man comes to the physician because of fatigue and recurrent infections. Examination shows massive splenomegaly without significant lymphadenopathy. Laboratory studies reveal pancytopenia. Bone marrow aspiration is unsuccessful due to a dry tap. Peripheral smear shows lymphocytes with fine cytoplasmic projections. Which of the following is the most likely diagnosis?
Answer choices
- AMultiple myeloma
- BPrimary myelofibrosis
- CHairy cell leukemiaCorrect answer
- DAcute lymphoblastic leukemia
- EFollicular lymphoma
- FSplenic marginal zone lymphoma
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