Hematologic Malignancies USMLE Step 1 Practice Question
A 61-year-old woman presents with episodic burning pain and erythema of her fingertips exacerbated by cold exposure. Vital signs show BP 138/82, HR 94, RR 16, temp 37.1°C, SpO2 98%. Laboratory studies reveal platelet count 920,000/mm³, hemoglobin 13.2 g/dL, WBC 7,200/mm³, and normal leukocyte differential. Bone marrow biopsy shows increased megakaryocytes. Patient denies aspirin use. Which of the following is the most likely diagnosis?
Answer choices
- AEssential thrombocythemiaCorrect answer
- BPolycythemia vera
- CAcute myeloid leukemia
- DImmune thrombocytopenia
- EMyelofibrosis
- FSecondary thrombocytosis due to iron deficiency anemia
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