Hematologic Malignancies USMLE Step 1 Practice Question
A 46-year-old man who lives at sea level is evaluated for elevated hemoglobin found on a work physical. He uses testosterone injections and snores loudly at night. Physical examination is unremarkable. Oxygen saturation is 91% while awake, and erythropoietin level is elevated. Which of the following is the most likely explanation for his erythrocytosis?
Answer choices
- AJAK2-driven autonomous red cell proliferation with suppressed EPO
- BDecreased hepcidin causing iron overload
- CDeficiency of ADAMTS13
- DInappropriate or appropriate elevation of EPO due to hypoxemia and androgen useCorrect answer
- ERelative increase in hematocrit caused by dehydration alone
- FPolycythemia vera with suppressed EPO
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