Glomerular Diseases USMLE Step 1 Practice Question
A 45-year-old woman with a 15-year history of type 2 diabetes presents with nephrotic syndrome. Vital signs: BP 154/92 mmHg, HR 88 bpm, RR 16, Temp 37°C, SpO2 98%. Labs reveal proteinuria 4.2 g/day, serum albumin 2.8 g/dL, creatinine 1.4 mg/dL, and hyperlipidemia. Urinalysis shows no hematuria. Renal ultrasound demonstrates normal kidney size. Kidney biopsy is performed. Which light microscopy finding most consistent with diabetic nephropathy?
Answer choices
- ANodular glomerulosclerosis (Kimmelstiel-Wilson lesions)Correct answer
- BCrescent formation with fibrinoid necrosis
- CSegmental endocapillary proliferation
- DSpike-and-dome subepithelial deposits
- EEosinophilic infiltration with granulomas
- FSegmental glomerulosclerosis with hyalinosis (FSGS)
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