Glomerular Diseases USMLE Step 1 Practice Question
A 24-year-old woman with photosensitivity, oral ulcers, and polyarthritis presents with hematuria and proteinuria. Vital signs show BP 138/88 mmHg, HR 92/min, RR 16/min, temperature 37.2°C, SpO2 98% on room air. Laboratory studies reveal serum creatinine 1.2 mg/dL, low C3 and C4 complement levels, and positive anti-dsDNA antibodies. Urinalysis shows no casts. Renal biopsy demonstrates diffuse proliferative glomerulonephritis with characteristic wire-loop capillary lesions. Which diagnosis best explains these findings?
Answer choices
- AIgA nephropathy
- BAmyloidosis
- CMinimal change disease
- DFSGS
- EDiffuse proliferative lupus nephritisCorrect answer
- FAnti-GBM disease (Goodpasture syndrome)
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