Glomerular Diseases USMLE Step 1 Practice Question
A 16-year-old girl presents with facial edema and cola-colored urine for 2 weeks. Vital signs show BP 148/92 mmHg, HR 88 bpm, RR 16, temp 37°C, SpO2 98%. Serum creatinine is 1.2 mg/dL (baseline 0.8), and complement C3 is markedly reduced. Urinalysis reveals 3+ proteinuria and dysmorphic RBCs. Renal biopsy demonstrates hypercellular glomeruli with characteristic tram-track appearance on light microscopy. She denies recent upper respiratory infection. Which diagnosis is most likely?
Answer choices
- AAlport syndrome
- BMembranoproliferative glomerulonephritisCorrect answer
- CAcute interstitial nephritis
- DFSGS
- EMinimal change disease
- FPoststreptococcal glomerulonephritis
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