Glomerular Diseases USMLE Step 1 Practice Question
A 58-year-old woman with recurrent sinusitis and hemoptysis presents with rapidly progressive renal failure. Vital signs: BP 152/94 mmHg, HR 102, RR 22, Temp 37.2°C, SpO2 94% on room air. Urinalysis reveals RBC casts and dysmorphic RBCs; serum creatinine is 3.8 mg/dL (baseline 0.9). Chest X-ray shows pulmonary infiltrates. Renal biopsy demonstrates crescent formation with minimal immune deposition on immunofluorescence. She denies antibiotic use. Which antibody is most likely positive?
Answer choices
- AAnti-mitochondrial antibody
- Bc-ANCA against proteinase 3Correct answer
- CAnti-SSA antibody
- DAnti-centromere antibody
- EAnti-phospholipase A2 receptor antibody
- FAnti-glomerular basement membrane antibody
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