Glomerular Diseases USMLE Step 1 Practice Question
A 27-year-old man presents with hemoptysis and cola-colored urine. Vital signs show BP 148/92 mmHg, HR 102/min, RR 20/min, SpO2 94% on room air. Chest imaging reveals diffuse alveolar infiltrates. Urinalysis shows dysmorphic RBCs with RBC casts; proteinuria is 1.2 g/24 hours. Serum creatinine is 2.1 mg/dL. He denies recent infections. Which immunofluorescence pattern on kidney biopsy is most likely?
Answer choices
- ANo immune deposits on immunofluorescence
- BLinear IgG deposition along the glomerular basement membraneCorrect answer
- CSubepithelial granular immune deposits
- DCongo red-positive fibrils
- EGranular mesangial IgA deposition
- FGranular IgG and complement deposition in a diffuse pattern throughout the glomeruli
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