Glomerular Diseases USMLE Step 1 Practice Question
A 57-year-old man with poorly controlled type 2 diabetes mellitus for 20 years presents with bilateral ankle edema. Vital signs: BP 156/94 mmHg, HR 88, RR 16, Temp 37°C. Urinalysis reveals heavy proteinuria (4.5 g/day); serum albumin is 2.8 g/dL. Funduscopic examination demonstrates diabetic retinopathy. Urinary casts are absent. Which renal biopsy finding is most likely present?
Answer choices
- AMesangial IgA deposition
- BSubepithelial humps
- CDiffuse podocyte foot process effacement only
- DLinear IgG deposition
- ENodular glomerulosclerosisCorrect answer
- FSubepithelial spike-and-dome deposits (membranous)
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