Glomerular Diseases USMLE Step 1 Practice Question
A 63-year-old man with a 45 pack-year smoking history presents with nephrotic syndrome. Vital signs show BP 142/88 mmHg, HR 88/min, RR 16/min, temperature 37.2°C, and SpO2 98% on room air. He reports unintentional 8-kg weight loss over 2 months and denies fever. Serum albumin is 2.1 g/dL. Renal biopsy demonstrates diffuse capillary wall thickening with granular subepithelial immune deposits. Which underlying condition most likely explains this renal pathology?
Answer choices
- ALung carcinomaCorrect answer
- BPolycystic kidney disease
- CRenal cell carcinoma
- DAcute pyelonephritis
- EAnalgesic nephropathy
- FIgA nephropathy (Berger disease)
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