Glomerular Diseases USMLE Step 1 Practice Question
A 48-year-old woman presents with progressive bilateral leg edema and frothy urine for 6 weeks. Vital signs show BP 138/88 mmHg, HR 82/min, RR 16/min, temp 37°C. Laboratory studies reveal nephrotic-range proteinuria (8.2 g/24 hours), serum albumin 2.1 g/dL, and positive anti-phospholipase A2 receptor antibodies. Urinalysis shows no hematuria. She denies fever or recent infections. Which renal biopsy finding is most likely present?
Answer choices
- AMesangial IgA deposition
- BWire-loop lesions with anti-dsDNA antibodies
- CSubepithelial immune complex deposits with spike and dome appearanceCorrect answer
- DDiffuse foot process effacement with normal light microscopy
- ELinear IgG deposition along the basement membrane
- FGranular IgG deposition along the capillary wall with crescent formation
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