Glomerular Diseases USMLE Step 1 Practice Question
A 36-year-old man with HIV presents with progressive bilateral lower extremity edema and frothy urine. Vital signs: BP 128/82 mmHg, HR 92/min, RR 16/min, Temp 37°C, SpO2 98%. Laboratory studies reveal serum albumin 2.1 g/dL, 24-hour urine protein 8.2 g, and serum creatinine 1.0 mg/dL. Urinalysis shows no hematuria. Renal biopsy demonstrates focal segmental glomerulosclerosis with hyalinosis on light microscopy. Which diagnosis best explains these findings?
Answer choices
- AAmyloidosis
- BMembranous nephropathy
- CMinimal change disease
- DDiabetic nephropathy
- EFocal segmental glomerulosclerosisCorrect answer
- FPost-infectious glomerulonephritis
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