Glomerular Diseases USMLE Step 1 Practice Question
A 5-year-old girl presents with periorbital and lower extremity edema and frothy urine 2 weeks after viral upper respiratory infection. Vital signs: BP 118/76 mmHg, HR 98/min, RR 22/min, Temp 37.2°C, SpO2 98% on room air. Serum albumin is 2.1 g/dL with nephrotic-range proteinuria (8.5 g/24 hours). Urinalysis shows no hematuria. Her nephrologist initiates empiric therapy without renal biopsy because the most likely disorder characteristically responds dramatically to which of the following treatments?
Answer choices
- APlasmapheresis
- BACE inhibitor monotherapy only
- CCyclophosphamide
- DBroad-spectrum antibiotics
- EHigh-dose corticosteroidsCorrect answer
- FMycophenolate mofetil monotherapy
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