Glomerular Diseases USMLE Step 1 Practice Question
A 6-year-old boy presents with a 1-week history of abdominal pain, arthralgia, and palpable purpura on his buttocks and lower extremities. Vital signs show BP 118/76 mmHg, HR 98/min, RR 22/min, and temperature 37.2°C. Urinalysis reveals microscopic hematuria and mild proteinuria (1+). Serum creatinine is 0.8 mg/dL. Blood cultures are negative. Platelet count is normal. Which renal histopathologic lesion is most likely present?
Answer choices
- ASubepithelial immune complex humps
- BDiffuse podocyte foot process effacement
- CMesangial IgA depositionCorrect answer
- DLinear IgG deposition on the glomerular basement membrane
- ENodular mesangial sclerosis
- FMesangial C3 deposition (C3 glomerulopathy)
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