General Pathology USMLE Step 1 Practice Question
A 43 year old man with chronic hepatitis B develops hepatocellular injury mediated by cytotoxic T lymphocytes. Liver biopsy shows hepatocytes undergoing apoptosis with condensed chromatin and intact membranes. Which of the following molecules released by CD8 positive T cells most directly triggers this process by entering target cells and activating caspases?
Answer choices
- AElastase
- BNitric oxide
- CHistamine
- DC5a
- EGranzyme BCorrect answer
- FPerforin
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