Endocrine Pharmacology USMLE Step 1 Practice Question
A 39-year-old woman with Cushing disease presents for pituitary ACTH reserve testing. Vital signs show BP 148/92, HR 88, RR 14, Temp 37°C. She has central obesity and proximal muscle weakness but denies headaches. Baseline cortisol is 32 mcg/dL (elevated). A drug inhibiting 11β-hydroxylase is administered, causing cortisol to decrease and 11-deoxycortisol to increase substantially. She takes no prior medications. Which drug was most likely administered?
Answer choices
- AHydrocortisone
- BMetyraponeCorrect answer
- CFludrocortisone
- DKetoconazole
- ERadioactive iodine
- FMitotane
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