Endocrine Pharmacology USMLE Step 1 Practice Question
A 37-year-old man with small cell lung carcinoma presents with ectopic ACTH production causing severe hypercortisolism. Vital signs show BP 168/98 mmHg, HR 102/min, RR 18/min, temp 37.2°C. Laboratory studies reveal 24-hour urine free cortisol 892 mcg/day (normal <50) and elevated ACTH 156 pg/mL. He denies recent infections. While awaiting definitive cancer treatment, he is started on a medication that inhibits 11β-hydroxylase and carries risks of hepatotoxicity and gynecomastia. Which drug was most likely prescribed?
Answer choices
- AHydrocortisone
- BFludrocortisone
- CMetyrapone
- DDexamethasone
- EKetoconazoleCorrect answer
- FMitotane
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