Endocrine Pharmacology USMLE Step 1 Practice Question
A 31-year-old woman with Graves disease presents with fever (38.9°C), severe pharyngitis, and malaise 6 weeks after initiating antithyroid therapy. Vital signs show tachycardia (102/min) and tachypnea (18/min). Laboratory evaluation reveals marked neutropenia (WBC 1,200/μL with absolute neutrophil count 400/μL) and normal thyroid function tests. Pregnancy test is negative. She denies recent infections or other medications. Which antithyroid drug most likely caused this agranulocytosis?
Answer choices
- ADesmopressin
- BRadioactive iodine
- CPropranolol
- DMethimazoleCorrect answer
- ELevothyroxine
- FPotassium iodide
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