Endocrine Pharmacology USMLE Step 1 Practice Question
A 35-year-old woman with Hashimoto thyroiditis started levothyroxine replacement 3 months ago. She presents with persistent fatigue, constipation, and weight gain despite medication compliance. Vital signs: BP 128/82, HR 58, RR 14, Temp 36.8°C. TSH 8.2 mIU/L (elevated). She denies palpitations or tremor. She takes her thyroid hormone each morning with prenatal vitamins and calcium carbonate supplement. Which of the following best explains her inadequate therapeutic response?
Answer choices
- APropylthiouracil
- BMethimazole
- CLevothyroxineCorrect answer
- DPotassium iodide
- ELiothyronine
- FCalcium carbonate supplement
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