Endocrine Pharmacology USMLE Step 1 Practice Question
A 43-year-old woman with a 6-year history of obesity and type 2 diabetes mellitus presents to her primary care physician for a routine follow-up. Her current medications include metformin 1000 mg twice daily, but her glycemic control remains suboptimal. Her HbA1c is 8.9%, fasting glucose is 187 mg/dL, and her BMI is 36 kg/m². Blood pressure is 134/86 mmHg, heart rate is 78 bpm, and physical examination reveals acanthosis nigricans along the posterior neck. She expresses strong interest in a medication that can improve glycemic control while also promoting weight loss. Her physician starts a once-weekly injectable drug that increases glucose-dependent insulin secretion, decreases glucagon release, and slows gastric emptying. Which of the following drugs was most likely prescribed?
Answer choices
- APramlintide
- BMetformin
- CSitagliptin
- DSemaglutideCorrect answer
- EGlyburide
- FDulaglutide
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