Endocrine Pharmacology USMLE Step 1 Practice Question
A 55-year-old woman with type 2 diabetes mellitus presents with fatigue and polyuria. Vital signs show BP 138/82 mmHg, HR 88/min, RR 16/min, temperature 37°C, SpO2 98% on room air. Recent fasting glucose is 186 mg/dL; HbA1c is 8.2%. She denies chest pain or dyspnea. Her physician initiates an oral antidiabetic agent that increases endogenous insulin secretion by closing ATP-sensitive potassium channels in pancreatic beta cells. Which drug works by this mechanism?
Answer choices
- APioglitazone
- BMetformin
- CEmpagliflozin
- DAcarbose
- EGlyburideCorrect answer
- FGlimepiride
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