Endocrine Pharmacology USMLE Step 1 Practice Question
A 49-year-old obese man presents to his primary care physician for a routine follow-up after being diagnosed with type 2 diabetes mellitus three weeks ago during an employee health screening. He reports no polyuria or polydipsia but notes fatigue with moderate exertion. He has a 10-year history of hypertension managed with lisinopril and denies any history of chronic kidney disease or liver disease. His BMI is 34 kg/m², blood pressure is 138/86 mmHg, and heart rate is 78 beats per minute. Fasting glucose is 168 mg/dL, hemoglobin A1c is 8.0%, serum creatinine is 0.9 mg/dL, and eGFR is 92 mL/min/1.73m². His physician initiates first-line pharmacotherapy that primarily decreases hepatic gluconeogenesis and is associated with weight loss rather than weight gain. Which of the following drugs was most likely prescribed?
Answer choices
- ASemaglutide
- BMetforminCorrect answer
- CPioglitazone
- DGlyburide
- ENPH insulin
- FSitagliptin
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