Endocrine Pharmacology USMLE Step 1 Practice Question
A 58-year-old man with a 12-year history of type 2 diabetes mellitus presents to his primary care physician reporting recurrent episodes of diaphoresis, tremulousness, and confusion occurring between 4:00 and 6:00 PM over the past two weeks. He administers a single insulin injection each morning at 7:00 AM and reports eating a consistent lunch at noon. His fingerstick glucose during one episode measured 48 mg/dL, which resolved promptly after oral glucose administration. His HbA1c is 7.1%, blood pressure is 128/76 mmHg, and BMI is 29 kg/mĀ². He denies skipping meals or increasing physical activity. His current insulin formulation is characterized by an intermediate duration of action and a pronounced pharmacodynamic peak occurring approximately 6 to 8 hours after subcutaneous injection. Which of the following drugs is most likely responsible?
Answer choices
- AInsulin glargine
- BInsulin lispro
- CInsulin degludec
- DRegular insulin
- ENPH insulinCorrect answer
- FInsulin detemir
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