Diabetes Mellitus USMLE Step 1 Practice Question
A 53-year-old man presents with a 6-month history of fatigue, chronic diarrhea, and 8-kg weight loss. He reports a recurrent blistering rash that appears in crops on his lower extremities, perineum, and around his mouth. The lesions progress through vesicular, pustular, and crusted stages before healing, leaving areas of bronze-colored induration. Vital signs are stable. Laboratory studies show: fasting glucose 236 mg/dL, hemoglobin 10.1 g/dL (MCV 85 fL), and a serum albumin of 3.2 g/dL. Abdominal ultrasound reveals a 3-cm solid mass in the pancreatic head. Which of the following cell types is most likely the origin of this neoplasm?
Answer choices
- APancreatic acinar cells
- BPancreatic α-cellsCorrect answer
- CPancreatic β-cells
- DPancreatic δ-cells
- FIntestinal enterochromaffin-like cells
- EGastric G-cells
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