Diabetes Mellitus USMLE Step 1 Practice Question
A 31-year-old pregnant woman at 26 weeks gestation presents with fatigue and polyuria. Vital signs: BP 118/76 mmHg, HR 88/min, RR 16/min, temp 37°C. Fasting glucose is 126 mg/dL; HbA1c is 6.2%. She denies gestational diabetes history and takes prenatal vitamins only. Previous glucose tolerance testing before pregnancy was normal. Which hormone produced during pregnancy most directly contributes to the insulin resistance observed in this patient?
Answer choices
- AHuman placental lactogenCorrect answer
- BTSH
- CProlactin from the posterior pituitary
- DOxytocin
- EProgesterone from the corpus luteum only
- FEstrogen from the ovaries and placenta
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