Diabetes Mellitus USMLE Step 1 Practice Question
A 19 year old woman with type 1 diabetes is brought for abdominal pain, vomiting, and rapid deep breathing after missing several insulin doses. Laboratory studies show glucose 520 mg/dL, high anion gap metabolic acidosis, and positive serum ketones. Which of the following is the major metabolic driver of her acid base disorder?
Answer choices
- AMarked increase in insulin mediated glucose uptake
- BIncreased lipolysis with hepatic ketone productionCorrect answer
- CIncreased renal bicarbonate regeneration
- DInhibition of hormone sensitive lipase
- EDecreased hepatic gluconeogenesis
- FElevated plasma lactate from impaired tissue perfusion
See the full explanation
Get the correct-answer rationale, why each distractor is wrong, the underlying mechanism, and high-yield associations — plus adaptive practice that targets your weak areas — with a free MedBoardPRO account.