Diabetes Mellitus USMLE Step 1 Practice Question
A 35-year-old woman presents with episodic severe headaches and diaphoresis. Vital signs show BP 168/104 mmHg, HR 102 bpm, RR 16, temperature 37.2°C. Physical examination reveals a firm thyroid nodule. Laboratory studies demonstrate elevated plasma free metanephrines (420 pg/mL), serum calcium 11.2 mg/dL with parathyroid hyperplasia on imaging, and calcitonin 285 pg/mL. Fasting glucose is normal. Fine-needle aspiration biopsy confirms medullary thyroid carcinoma. Which syndrome best explains this clinical presentation?
Answer choices
- AWermer syndrome unrelated to parathyroid disease
- BMEN 1
- CMEN 2B
- DMEN 2ACorrect answer
- EMcCune Albright syndrome
- FFamilial medullary thyroid carcinoma without other endocrine manifestations
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