Diabetes Mellitus USMLE Step 1 Practice Question
A 45-year-old woman with a 3-year history of hypertension presents with persistent blood pressure elevation (168/105 mmHg) despite lisinopril and hydrochlorothiazide therapy. She reports intermittent muscle cramps and generalized weakness. Vital signs show heart rate 88/min, respiratory rate 16/min. Laboratory studies reveal potassium 2.9 mEq/L, bicarbonate 33 mEq/L, elevated plasma aldosterone concentration, and suppressed plasma renin activity. Serum glucose and renal function are normal. Which of the following is the most likely diagnosis?
Answer choices
- ASyndrome of inappropriate ADH secretion
- BSecondary hyperaldosteronism due to renal artery stenosis
- CPrimary hyperaldosteronismCorrect answer
- DPheochromocytoma
- EAdrenal insufficiency
- FHypokalemic metabolic alkalosis secondary to loop diuretic overuse
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