Coronary Artery Disease USMLE Step 1 Practice Question
A 12 year old boy is brought to the clinic because of fever, migratory joint pain, and shortness of breath 3 weeks after a sore throat that resolved without treatment. Examination shows a new holosystolic murmur at the apex and tender swollen knees and ankles. Which of the following is the most likely mechanism of his cardiac disease?
Answer choices
- ADirect bacterial invasion of the valve leaflets
- BAutoimmune cross reactivity to streptococcal M proteinCorrect answer
- CFibrocalcific degeneration due to aging
- DToxin mediated endothelial injury by Corynebacterium
- EImmune complex deposition from chronic hepatitis
- FDirect bacterial invasion of cardiac valves by group A Streptococcus
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