Chronic Kidney Disease USMLE Step 1 Practice Question
A 33 year old man with untreated HIV presents with worsening edema and frothy urine. Laboratory studies show hypoalbuminemia and heavy proteinuria. Kidney biopsy demonstrates sclerosis involving some but not all glomeruli and affecting only portions of the involved glomeruli. Which of the following best describes the mechanism of this disease?
Answer choices
- APodocyte injury with nonselective protein lossCorrect answer
- BImmune complex deposition after streptococcal infection
- CDeposition of misfolded transthyretin in glomeruli
- DAntibody mediated attack on basement membrane collagen
- EMesangial deposition of IgA following mucosal infection
- FHepatitis C cryoglobulinemic glomerulonephritis from immune complex deposition
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