Chronic Kidney Disease USMLE Step 1 Practice Question
A 19 year old college student develops cola colored urine 1 day after the onset of sore throat and fever. He has had two similar episodes after respiratory infections in the past. Blood pressure and kidney function are normal. Which of the following is the most likely underlying mechanism of this patient's renal disease?
Answer choices
- AGranular deposition of DNA anti DNA immune complexes with low complement
- BSubepithelial deposition of immune complexes after streptococcal skin infection
- CMesangial deposition of aberrantly glycosylated IgA containing immune complexesCorrect answer
- DNephrin mutation causing loss of slit diaphragm integrity
- EAntibodies directed against type IV collagen in the basement membrane
- FC3 nephritic factor stabilizing C3 convertase causing persistent hypocomplementemia
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