Chronic Kidney Disease USMLE Step 1 Practice Question
A 7-year-old boy presents with growth delay and bone pain. Vital signs show BP 118/76 mmHg, HR 92 bpm, RR 20/min, temp 37°C, SpO2 98%. Labs reveal metabolic acidosis (pH 7.28), serum creatinine 1.2 mg/dL, glucosuria with normal serum glucose 95 mg/dL, aminoaciduria, and phosphaturia. Skeletal survey demonstrates rickets. He denies polyuria. Which diagnosis best explains this constellation of proximal tubule dysfunction with chronic kidney disease?
Answer choices
- ARenal artery stenosis
- BFanconi syndromeCorrect answer
- CNephrogenic diabetes insipidus
- DLiddle syndrome
- EType 1 renal tubular acidosis
- FX-linked hypophosphatemic rickets from FGF23-mediated phosphate wasting
See the full explanation
Get the correct-answer rationale, why each distractor is wrong, the underlying mechanism, and high-yield associations — plus adaptive practice that targets your weak areas — with a free MedBoardPRO account.