Chronic Kidney Disease USMLE Step 1 Practice Question
A 54-year-old woman with recurrent calcium nephrolithiasis and hypertension (BP 158/92 mmHg, HR 78/min) is started on hydrochlorothiazide. Recent labs show serum creatinine 1.2 mg/dL, 24-hour urine calcium 320 mg/day, and serum calcium 9.8 mg/dL. She denies polyuria. Which of the following additional metabolic changes is most likely to occur as a result of this thiazide therapy?
Answer choices
- ADecreased urinary calcium excretionCorrect answer
- BIncreased serum potassium concentration
- CMetabolic acidosis
- DIncreased urine osmolality by ADH agonism
- EIncreased urinary calcium excretion
- FDecreased serum magnesium concentration
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